Abstract: Host-induced gene silencing (HIGS) is a new technology based on RNA interference (RNAi). HIGS can identify gene functions from the view of reverse genetics and create disease resistant varieties with persistent resistance and stable inheritance. Thus, HIGS provides a new perspective for promoting plant disease resistance. In the current paper, we discuss the principles of HIGS technology, summarize the latest research progress in enhancing plant resistance against fungal diseases, and analyze the advantages and disadvantages of HIGS. Future prospects of HIGS technology are also discussed, with a focus on in-depth study of plant resistance.