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陈丹, 彭雄波. DEAD-box基因家族在拟南芥生长发育中的作用[J]. 植物科学学报, 2016, 34(6): 941-948. DOI: 10.11913/PSJ.2095-0837.2016.60941
引用本文: 陈丹, 彭雄波. DEAD-box基因家族在拟南芥生长发育中的作用[J]. 植物科学学报, 2016, 34(6): 941-948. DOI: 10.11913/PSJ.2095-0837.2016.60941
CHEN Dan, PENG Xiong-Bo. DEAD-box: Function on Growth and Development in Arabidopsis thaliana[J]. Plant Science Journal, 2016, 34(6): 941-948. DOI: 10.11913/PSJ.2095-0837.2016.60941
Citation: CHEN Dan, PENG Xiong-Bo. DEAD-box: Function on Growth and Development in Arabidopsis thaliana[J]. Plant Science Journal, 2016, 34(6): 941-948. DOI: 10.11913/PSJ.2095-0837.2016.60941

DEAD-box基因家族在拟南芥生长发育中的作用

DEAD-box: Function on Growth and Development in Arabidopsis thaliana

  • 摘要: 在RNA代谢过程中,需要许多蛋白和核酸的参与,其中一类蛋白就是RNA解旋酶。RNA解旋酶通过水解ATP获得能量来参与RNA代谢的多个方面,包括核内转录、pre-mRNA的剪切、核糖体发生、核质运输、蛋白质翻译、RNA降解、细胞器内基因的表达。DEAD-box蛋白家族是RNA解旋酶中最大的亚家族,它具有9个保守结构域,因motify Ⅱ的保守氨基酸序列Asp-Glu-Ala-Asp(DEAD)而命名。该家族在酵母、拟南芥(Arabidopsis thaliana Heynh.)和人类基因组中都有较多的家庭成员。近年来,研究者对拟南芥DEAD-box蛋白家族的结构和功能进行了一些研究,本文着重总结DEAD-box基因家族对拟南芥生长发育的影响。

     

    Abstract: Many RNA molecules require proteins and other nucleic acids to assist in RNA metabolism. RNA helicases are such proteins, and participate in nearly all aspects of RNA metabolism, including transcription, pre-mRNA splicing, ribosome biogenesis, transport between the nucleus and cytoplasm, protein translation, nonsense-mediated decay, and organelle-specific RNA metabolism, in an ATP-dependent manner. The DEAD-box protein family of RNA helicases belong to superfamily Ⅱ. They have nine conserved motifs, and are named for the conserved amino acid sequence Asp-Glu-Ala-Asp(D-E-A-D) in motif Ⅱ. DEAD-box families consist of abundant members in Saccharomyces cerevisiae, Arabidopsis thaliana, and humans. Recently, the functions of some DEAD-box proteins were revealed in Arabidopsis. This review focuses on the functions of DEAD-box proteins on the growth and development of A. thaliana.

     

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